Drug Repositioning: Approaches and Applications for Neurotherapeutics

This book reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders.

Stroke is a major cause of death and long-term disability worldwide. Pharmacological or mechanical recanalization is currently the only approved strategy for the acute treatment of this disease. Thus, researchers in the field now face the crucial need to develop effective therapies and successfully translate novel strategies into the clinical setting. By bringing together the experience of accomplished stroke researchers and clinicians, the book presents the most promising preclinical approaches and the most updated clinical evidence for the treatment and management of stroke patients.